Parameters of oxidative stress in children with Type 1 diabetes mellitus and their relatives.
Oxidative stress (OS) plays an important role in the pathogenesis of Type 1 diabetes mellitus (DM). The aim of the study was to compare OS parameters in diabetic children and their first-degree relatives. Fifty diabetic children from the West Bohemian Region were examined as well as their 32 siblings (12 Boys and 20 girls) and 65 of their parents during a period of 6 months.
Thirty ealthy sex- and age-matched children studied before planned surgeries were normal controls for children, 40 healthy adult volunteers were controls for parents. OS parameters were evaluated in all participants of the study (superoxide dismutase, SOD; glutathione peroxidase, GSHPx; plasma antioxidant capacity, AOC; reduced glutathione, GSH; and malondialdehyde, MDA) and also Type 1 DM-associated antibodies (ICA and GADA). The results in diabetic children showed significantly lower GSHPx and AOC and increased MDA when compared with healthy children. Similar findings were found in their siblings but without statistical significance. It is consequently evident that decreased antioxidative protection and simultaneous free radical (FR) overproduction occur in diabetic children and that there is a similar, but not significant, tendency in their siblings. The findings warrant reducing OS in diabetic children and postponing disease onset in susceptible relatives.
TUESDAY, July 23 (HealthScoutNews) — People with diabetes who have trouble reading appear almost twice as likely to have poorly controlled blood sugar and serous long-term complications than diabetics ( news – web sites) who have no difficulty reading. A new study, published in tomorrow’s Journal of the American Medical Association ( news – web sites), is the first to show low literacy can cause health problems for people with a chronic medical condition. “Having diabetes and difficulty reading creates a double bind. Diabetes patients rely on a number of tools to manage their disease and prevent serious health problems.
For patients with low literacy, it’s as though they have received the toolkit, but not the operating instructions,” says study author Dr. Dean Schillinger, an assistant professor of medicine at San Francisco General Hospital Medical Center. “Because our health system expects patients to be able to read at a very high level, we may be leaving a lot of patients in the dark,” Schillinger adds in a prepared statement. The study included 408 people with Type II diabetes, which affects more than 16 million Americans, including 18 percent of all people aged 65 and older.
The study found that 36 percent of the study participants with inadequate health literacy had diabetic retinopathy, compared to 19 percent of the people with adequate health literacy. Diabetic retinopathy is an eye condition that can be a precursor to blindness. Optimal blood sugar control can prevent retinopathy. The study found 20 percent of the people with inadequate health literacy had optimal blood sugar control, compared to 33 percent of the people with higher health literacy.
The findings were similar for other diabetes complications, such as kidney disease, amputation and heart disease, according to the study.
Scientists have found two surprising causes of diabetes — a pair of genes that didn’t seem to have anything to do with the disease.
Defects in either gene cause an unusual variant of the most common kind of diabetes.
Nobody knows why. But by showing that the genes can sabotage the body’s efforts to rein in high blood sugar levels, the new work “opens up a whole new pathway that has to be explored” to understand diabetes, said researcher Graeme Bell. And that might lead to new treatments.
The vast majority of diabetes is type 2 disease, which affects about 15 million Americans. It usually develops in people older than 40, especially if they’re overweight.
In contrast, the variant caused by the genes usually appears before age 25, often in adolescence or childhood. Together, the genes may account for 2 percent to 5 percent of type 2 cases, Bell said.
Bell is a professor of biochemistry, molecular biology and medicine at the Howard Hughes Medical Institute at the University of Chicago. He and an international team of researchers presented their findings in Thursday’s issue of the journal Nature.
In diabetes, blood sugar levels rise out of control because the body doesn’t secrete enough insulin, doesn’t respond normally to insulin, or has both problems. Diabetes can lead to such problems as kidney disease, blindness and nerve damage. The nerve damage and impaired circulation in the feet and legs can set the stage for amputation.
The variant caused by the genes is called maturity-onset diabetes of the young, or MODY. Another MODY gene had been found before, and Bell said at least one more remains to be uncovered.
The two genes in his study were already known to scientists, mostly for turning on other genes in the liver. The genes are also active in the intestine, kidney and the pancreas, which makes insulin, but it’s not clear what they do in those organs.
People with MODY don’t secrete enough insulin to handle high blood sugar levels, and it’s not clear yet why defects in the two genes would lead to that problem, Bell said.
The work suggests that as scientists hunt for genes that make people vulnerable to type 2 diabetes, they should consider those that regulate other genes, he said.
In an accompanying commentary, John Todd of Oxford University said the findings add “an exciting new dimension” to knowledge about the biology of diabetes and to the hunt for genes linked to common diabetes.
I am newly diagnosed diabetic. I have been told by a nutrionalist, who himself beat diabetes, that taking Chromium Complex, 200 mcg, 3 times per day with a meal can beat diabetes. My doctor also confirmed that he has heard of people who have done the same. Does anyone know of such stories where diabetes was beaten by taking the mineral Chromium? Also, anyone know of any other home remedy being used to defeat this miserable disease?
Any professional that deals with diabetics knows that there is NO CURE. You cannot BEAT diabetes. You CAN control it, but then you are a diabetic in control.
As for the supplement at hand… I take many supplements for many reasons, but I would take no supplement that touted a cure. It can only be snake oil.
As far as I know no one has ever been cured of diabetes.
If you have a gross deficit of any vitamin or mineral. Today few people ever face gross deficits.
A woman that has gestational diabetes may have all symptoms go away after pregnancy.
I can see where temporary high sugars can be caused by curable condition.
Chromium and a hundreds other items are touted as a “cure”. The only thing that ever helped me is tight control of blood sugars.
I see how some people might be able to delay the usual progress of the condition.
If anyone has a verifiable story of a cure I would like to hear about it.
Diabetes cure a long way away: researchers Periodic injections may reduce insulin dependency TORONTO (CP) – The search for a cure for diabetes got a $6-million boost Wednesday but researchers could offer little hope for an immediate breakthrough.
It’s been almost 80 years since Toronto’s Frederick Banting and Charles Best received the Nobel Prize for dis-covering insulin. Today, insulin, in pill or by injection, helps regulate blood sugar in many of the 2.5 million Canadians with diabetes.
But insulin only controls the disease.
The mission is to find a cure “ASAP,” said Dr. Terry Delovitch of the John P. Robarts Research Institute in London, Ont., but he gave a “realistic hope” of 20 years.
For parents like Cheryl Render, 20 years is too long. Her nine-year-old son Jared was diagnosed at age ree with a simple urine test. His symptoms were frequent uri-nation, weight loss while eating more than normaL mood-mess and irritability.
“He’s a nine-year-old kid who resents it” Render said, adding Jared still cheats by snacking on other kids’ foods, resulting in high blood sugar that makes him sweaty and jittery and could kill him.
In diabetes, the pancreas can’t metabolize sugar and starch properly, and blood and urine contain too much sugar, which can result in convulsions or a coma. But Render became a volunteer with the Juvenile Diabetes Foundation because she has hope. Her son plays hockey and lives normally thanks to the insulin injections he gives himself three times a day The $6 million is from the foundation and the Medical Research Council of Canada.
It will go toward three years of clinical testing to find new therapies for Type 1, or juvenile, diabetes. It usually hits children and young adults whose pancreas produce little or no insulin.
Type 2 diabetes strikes far more Canadians, many of whom don’t know they have it. The pancreas does not make enough insulin or the body is not able to use it efficiently.
Based on preliminary research, a cure may be a peri-odic injection of medication. It might get patients off insulin or reduce the frequency of its use, said Delovitch.
Dr. Jayne Danska, a senior scientist at the Hospital for Sick Children Research Institute, is trying to unrav-el the genetics of diabetes, which could result in a blood test to indicate who is most likely to get the dis-ease.
She said it would be “irresponsible to promise a spe-cific outcome in a specific time,” especially when talk-ing about a cure.
Danska said it was only in the last few years that Type 1 diabetes was found to be an autoimmune dis-ease – the immune system kills islets in the pancreas- rather than a defect in the islets themselves. In contrast to diseases such as cystic fibrosis and muscular dystrophy, caused by abnormalities in a sin-gle gene, Type 1 diabetes involves multiple genes which affect a variety of cells.
Danska added Canadian researchers are connected to scientists around the world who may make a dis-covery that would speed up scientific work here.
Delovitch, who studies immune-specific therapies, said antibody injections in mice have freed them of the disease for about a year.
Genetics and the immune system play a major role in why Type 1 diabetes strikes some people and not others, so finding the mechanism or mechanisms that lead to the disease is complicated, the researchers said.
This is why humans have not been tested with anti-bodies, although such testing could be on the horizon.
Updated: September 1, 1999 You will need the Adobe Acrobat® Reader to view the PDF files. Disclaimer: NOAH is an information guide only. This information has been culled from a variety of consumer health ..
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125. Diabetes Action Research and Education Foundation
Events, programs, tip of the week, links, and otherareas.
126. JDF – Nevada Chapter – Top
Click logo for: The diabetes supply and prescription drug mail-order source donating half its profits to diabetes research The Juvenile Diabetes Foundation is a not-for-profit, voluntary health agency whose mission is to support and fund research to find a cure for diabetes …
127. children with DIABETES – Diabetes Basics
Successful management of diabetes is as much about information as it is about insulin. Diabetes Basics is designed to supplement the information you receive from your Diabetes Team.
128. Diabetes Mortality Rapidly on the Rise
Joslin Diabetes Center’s Latest Diabetes News: Being Overweight May Be More in the Genes Than Previously Thought, Researchers Find
129. Joslin Diabetes Center- Information on diabetes, diet, exercise, …
Only US medical ctr dedicated solely to diabetes treatment, research, cure, education. Research news, lifestyle and nutrition information, discussion groups, directory of …
130. Gestational Diabetes – Obstetrics and Gynecology – MedStudents
On this text we are going to discuss the importance of gestational diabetes(GDM) with an emphasis on diagnostic criteria, medical and obstetric management. Pregnancy is a diabetogenic state characterized by increased insulin demand, increased diabetogenic horm
131. Diabetes Store
Tons and tons of books, CDs, and more, all at a discount. Now you can have chicken any way you want it! More than 150 great-tasting, low-fat chicken…
132. Diabetes Centre – Australia
diabetes – information, resources and discussion
133. Diabetes Handbook Table of Contents
THE HEALING HANDBOOK for PERSONS WITH DIABETES. Table of Contents. Title Page. Introduction. Chapter 1: What is Diabetes? Chapter 2: Coping with…
134. Diabetes Information Center – Diabetes-Related Web Sites
The Diabetes Information Center offers free information about Diabetes prevention, diagnosis, treatment, nutrition, herbal remedies, sugar-free recipes, Diabetes organizations, Diabetic Supplies, Treatment Centers and support
135. Diabetes Monitor
What’s New at The Diabetes Monitor.
diabetes-forum : Umfassende , strukturierte Informationen zum Thema Diabetes mellitus
137. Pumps It, Inc. – Managing Insulin Dependent Diabetes Through Insulin P…
Diabetes Action Research & Education Foundation. This web site provides weekly diabetes management tips and recipes for diabetics; offers a free booklet for people with diabetes; and outlines the services provided by this non-profit organization.
140. Diabetes Monitor: Diabetes on the Web: Table of Contents
Diabetes on the Web: Hodgepodges of hyperlinks to huge and humble homepages, websites, and webpages that have information about diabetes…. http://www.mdcc.com/other-ds.htm
141. March of Dimes: Diabetes in Pregnancy Facts. Fetal Risks. Pregnancy Complications. Preexisting Diabetes and Preconception Care. Screening for Gestational Diabetes. Diet. Exercise. Insulin. Home Glucose and …
a service of y-DNA, inc. AACE Guidelines for the Management of Diabetes Mellitus developed by the American Association of Clinical Endocrinologists and th American College of Endocrinology. 1995.
143. Manitoba Division of the Canadian Diabeties Association
is the largest non-governmental supporter of diabetes research, education and advocacy. Together with its sections and councils, its employees and volunteers, CDA plays an invaluable role in the everyday lives of the over 1.5 million Canadians who live with diabetes.
144. Site Map
Take Charge of Your Diabetes. 2nd edition. 1997. (English language patient guide) Controle Su Diabetes. 1997 (Spanish language patient guide) Diabetes Surveillance, 1997 – Online or PDF File Collection
145. Home Page for Cure Diabetes, Inc.
My name is Tom Dorsch, M.D. I am an adult endocrinologist in Peoria, Illinois. I believe a cure for diabetes must be found. The purpose of this site is to:
146. Low Vision Associates helps patients with low vision
The latest on low vision, whether from aging, injury, glaucoma, macular degeneration, albinism, retinits pigmentosa, diabetes or other causes, specialty lenses may help.
147. Diabetes Awareness from Beauregard Memorial Hospital
Page with links to Diabetes Awareness
148. Healthtouch – Diabetes
Diabetes Noninvasive Blood Glucose Monitors Devices To Take Insulin For Diabetes Alternative Therapies For Diabetes Additional Resources For & About Hispanic Americans With Diabetes Hypoglycemia (Low Blood Sugar) Dental Tips For Diabetics…
This dictionary of diabetes terms defines words that are often used when talking or writing about diabetes. It is designed for people who have diabetes and their families and friends. It provides basic …
Tons and tons of books, CDs, and more, all at a discount. Don’t believe the myths! Here’s the truth: You can eat sugar! You don’t have to exercise everyday! You can snack and eat out! There are many myths circulating about what people with diabetes
153. Diabetes, A Journal of the American Diabetes Association
For More Information Call Us at 1 (800) DIABETES 1 (800) 342-2383 or e- mail customerservice @diabetes.org You may submit a Change of Address for your American Diabetes Association Professional Membership by clicking here.
Comp-Pat-Able, diabetes, insulin, blood sugar and other diabetic information and links from around the world.
155. DIABETES RESOURCES NETWORK
Dedicated To Providing Diabetics With A Wealth Of Information, Education & Resources Materials
156. Diabetes Type 2
This information sponsored by The American Medical Association Adapted from Type II Diabetes: Reducing Your Risk Written by Donna Kotulak Acknowledgments Linda Bresolin Office of Women’s and Minority Health, AMA
Feline Diabetes is the original internet guide for cats who have diabetes. Since 1996 we have been a clearinghouse for information about the disease…
Welcome to the American Diabetes Association Journals Web Site! If you subcribe to a journal you can see abstracts, full text and PDF documents for free. If you do not subcribe to a journal you can see abstracts for free as well as purchase PDF…
159. Diabetes Insight – Books
Diabetes Insight Book Reviews.
160. Nephrogenic Diabetes Insipidus Foundation NDI Information & Resources
A foundation formed to support education, research, treatment, and cure for Nephrogenic Diabetes Insipidus.
161. How Avandia affects insulin use – Flash animation
Flash animation of how Avandia affects insulin use. Most people with type 2 diabetes develop insulin resistance before they develop the disease. Avandia targets insulin resistance to help the body use insulin more efficiently.
162. Diabetes risk test
163. Diabetes and Insulin Pump Therapy
Devoted to the free exchange of information about diabetes, insulin pumps diabetic complications, as well as advances in diabetic treatment for adults and children with diabetes. Lots of links, books, FAQs info on carbo-counting, mail lists, recipes, support groups and more…
164. On-line Diabetes Resources
Tracking Diabetes on the Web Since February 1995 Most Recent Update: September 20, 1999 A Comprehensive Directory of Substantative Information about Diabetes This is the first of 14 pages cataloging all the on-line ..
165. Information about the Humulin Pen and Humalog Pen from Eli Lilly and …
Eli Lilly and Company provides information about the new disposable insulin delivery devices, the Humulin Pen and Humalog Pen.
166. Directory of Diabetes Organizations
Department of Health and Human Services Department of Veterans Affairs Professional and Voluntary Associations Private Organizations This directory lists Government agencies, voluntary …
Helping Canadians suffering from kidney failure and related disorders such as high blood pressure, kidney stones, diabetes and urinary tract infections
168. Diabetes 101
Online resource for diabetics or those interested in diabetes. Diabetes 101 explains diabetes and related topics in an easy to read and understand guide. Everything from -what is diabetes- to -diabetic neuropathy-. A must for newly diagnosed diabeti
169. National Diabetes Education Program
National Diabetes Education Program A joint program sponsored by the National Institutes of Health and the Centers for Disease Control and Prevention
170. American Dietetic Association – Nutrition and Health Campaign for Women
Educating women about how making informed food choices can help them decrease their risk of heart disease, breast cancer, osteoporosis, diabetes, and obesity; and advocating for nutrition research on women’s health issues.
171. Pharmchem Nutrients Home Page
Alternative medicines and rainforest products. We sell freeze dried bitter melon for type II diabetes control.
172. Novo Nordisk Portugal
Novo Nordisk é o lider mundial em insulina e diabetes care Produz e comercializa uma grande variedade de produtos farmacéuticos.
Juvenile Diabetes Foundation Canada is an affiliate of the Juvenile Diabetes Foundation International, a worldwide organization founded in 1970 by parents of children with diabetes who were convinced that, with research, diabetes could be cured.
64. National Diabetes Education Initiative
An online resource for medical education programs on type 2 diabetes and insulin resistance.
65. Clinical Practice Recommendations: Screening for Diabetes
Clinical Practive Recommendation Screening for Diabetes
Whether you want to learn about living with diabetes on a daily basis, the latest advances in diabetes research or just the basic facts about…
67. Diabetes Prevention Program
The Diabetes Prevention Program is no longer recruiting new volunteers. The goal of recruiting 3,000 participants has been reached; final recruitment figures will be available shortly. (Click here to view the Press Release.) Please continue to browse this Web site for important …
A world leader in insulin and diabetes care and also manufactures and markets a variety of other pharmaceutical products. Furthermore the company is the world’s largest producer of industrial enzyme products. Headquartered in Denmark, Novo Nordisk has companies and information …
74. International Diabetes Web Site
Presented by the International Diabetes Institute in Australia.
75. Introduction to Juvenile Diabetes Foundation International
THE JUVENILE DIABETES FOUNDATION THE DIABETES RESEARCH FOUNDATION Mary Tyler Moore International Chairman Juvenile Diabetes Foundation International The Diabetes Research Foundation
76. Roche Diagnostics – Diabetes Care Home Page
77. Visit for the latest diabetes information on businesses, org…
Search Our Site Free News Our free weekly newsletter has all the latest diabetes research and business All the health that’s fit to print Children with Diabetesis loaded Scott and White Clinic in Texas has a great Online Education Manual The Doctor’s Guide to the Internet is …
Online drugstore, lowest price prescriptions, wellness store, vitamins, sports-nutrition, nutrition books, specializes in diabetes care, we can design your nutritional needs.
79. Diabetes Institutes Foundation
Non-profit organization supports diabetes research toward a cure and prevention of complications at the Strelitz Diabetes Institutes, Eastern Virginia Medical School.
80. CDC’s Diabetes and Public Health Resource
Diabetes Home What s New? About Our Program Diabetes FAQs Publications & Products Clip art State-based Programs Statistics Special Projects Links Feedback Site Map Welcome to CDC’s Diabetes and Public Health Resource. The Division of Diabetes..
81. CDC’s Diabetes-related Publications
Publications & Products Publications and products developed by CDC Take Charge of Your Diabetes. 2nd edition. 1997. (English language patient guide)
82. Clinical Practice Recommendations: Screening for Diabetes
Clinical Practive Recommendation Screening for Diabetes
83. MetaMedix is a developer of diabetes and health data management software
Diabetes and health data management through the use of software. Recipes, cookbooks, books and health food products. Mellitus Manager records blood sugars, insulin, carbohydrates and exercise to generate reports and graphs for monitoring diabetes. Zone Manager assists in the tedious …
Diabetes, die Zuckerkrankheit, ist eine schwere Stoffwechselerkrankung. Frauen sind von ihr häufiger betroffen, als Männer. Auf diesen Seiten erfahren Sie, welche Ursachen und und welche gesundheitlichen Schäden Diabetes haben kann. Sie erfahren etw
85. Diabetes Information
For More Information Call Us at 1 (800) DIABETES 1 (800) 342-2383 or e- mail customerservice @diabetes.org What is Diabetes and Who Gets It? Living With Diabetes
86. Pediatric Endocrinology
Information for medical students, residents and practioners about such subjects as diabetic ketoacidosis, diabetes insipidus and fluids and electrolytes.
Inside Excite Zodiac Gift GuideFind gift ideas for each sign Hollywood PhotosSee stars dressed to impress Excite Medical Encyclopedia Diabetes mellitus: A disorder caused by decreased production of insulin, or by decreased ability to use insulin.
101. Diabetes Monitor: Diabetes on the Web: Table of Contents
Diabetes on the Web: Hodgepodges of hyperlinks to huge and humble homepages, websites, and webpages that have information about diabetes.
102. General Diabetes Web Sites
Diabetes Sites on the World Wide Web International Organisations National Organisations United Kingdom diabetes related web sites Diabetes Journals International Organisations International Diabetes Federation St Vincent Declaration St Vincent..
104. Sympatico Health Links Reviews: American Diabetes Association
From the HealthyWay online health and wellness resource for Canadians, you have access to Health Links with more than 6,500 of the best sites and resources on the Internet, listings of 4,000 Canadian health and medical associations links to thousands of other sites
110. Welcome to the Diabetes Foundation of Mississippi!
The Diabetes Foundation Of Mississippi has information to help you learn more about diabetes. Whether you have diabetes, know someone who does, or just want the facts, our goal is help you cope effectively. (Right- *Miss America helps Mississippians cope).
111. Dr. Socks
We are the source for specialty socks. We specialize in socks developed specifically for people with diabetes, arthritis or general foot problems.
112. Few facts about diabetes – Joslin Diabetes Center
A Few Facts About Diabetes: diabetes types, meal planning, insulin injections, oral agents, and blood sugar monitoring.
Wichtige Adressen für Diabetiker und ihre Verwandten: Fachkliniken, Schulungszentren, Schwerpunktpraxen, Psychologische Beratungsstellen, Fachbuchversand, ‘Diabetes im Netz’
115. Diabetes Monitor: The Diabetes Mentor
The Diabetes Mentor: A collection of diabetes handouts for patients and their families. From the Diabetes Monitor.
116. IDC Publishing
Welcome to IDC Publishing, where you’ll find best-selling books on healthy eating, along with some of the most popular books available for people with diabetes.
117. Diabetes Diet
Services available for diabetics and people who experience hypoglycemia; insights about diet, vitamins and medications by Pharmacist Diabetes Educator Nutritionist
118. Discount Medical Supplies
Discount health products and medical supplies including first aid kits, medical supply equipment, wheelchairs, uniforms, hospital beds, diabetic and diabetes supplies, and carpel tunnel wrist wraps.
119. children with DIABETES – Diabetes Clinic
The Diabetes Clinic at children with DIABETES is your on-line source for medical information about Type 1 diabetes. You can count on us to bring you the latest information about research, management techniques, and meal planning.
120. Diabetes and Hypoglycemia Forum on Compuserve Home Page
Diabetes and Hypoglycemia Forum on Compuserve Welcome to the Diabetes and Hypoglycemia Forum on Compuserve Home Page. This page is set up as a public service to diabetics, their families, friends, medical professionals, and people with an interest.
Diabetes was called sugar diabetes in the past. I have articles where sugar was the culprit in diabetes. They would publish data showing the correlation between sugar consumption and diabetes.
The fact that was ignored is a person that is developing diabetes may develop severe desire for sugars. I have seen this happen to several people. They are starving in a sea of glucose. No insulin. People say —SEE They consumed a lot sugar and it gave them diabetes.
We finally seem to be getting over that but we still are trying to blame diet for diabetes. The problem I sense is it is limiting our effort at finding the real causes.
About the same as stomach ulcers. The routines there was to give a very “exact”reasons for the cause of that problem. All of them proved to be wrong.
The aversion of carbs is the speed of their action. It seems to be easier to control blood sugars with use of protein and fat. I worry that the short time benefits may be a long term problem
I see it this way. Diabetics have a damaged blood sugar control system. They must limit the load on that system. The only way to do that is to limit food input. The type of food is secondary except we need a balance to get the needs of our body.
But weight loss is a plus in most people.
Sugar free may not mean calorie free. Another sales gimmick
Only my opinion. The issue is very complex and all diabetics are not the same.